Cefpet CLV 325 is a combination antibiotic tablet by Intas Pharmaceuticals containing Cefpodoxime Proxetil and Potassium Clavulanate. It combines a third-generation cephalosporin with a beta-lactamase inhibitor — specifically designed for bacterial infections that involve organisms resistant to standard cefpodoxime treatment. It is indicated for dogs and cats and requires a valid veterinary prescription.
Composition
| Active Ingredient |
Strength per Tablet |
| Cefpodoxime Proxetil |
200mg |
| Potassium Clavulanate |
125mg |
Indications — What Cefpet CLV 325 Treats
Cefpet CLV 325 is prescribed for the following bacterial infections in dogs and cats:
- Skin and soft tissue infections — including deep pyoderma and infected wounds
- Perioperative surgical care — prevention and treatment of post-surgical bacterial infections
- Gastrointestinal infections
- Urinary tract infections (UTI)
- Upper respiratory tract infections
- Lower respiratory tract infections
How Cefpet CLV 325 Works
Cefpodoxime Proxetil is a third-generation cephalosporin that kills bacteria by inhibiting bacterial cell wall synthesis. However, certain bacteria produce beta-lactamase enzymes that break down and inactivate standard cephalosporin antibiotics — making them ineffective against resistant strains.
Potassium Clavulanate is a beta-lactamase inhibitor. It binds irreversibly to these enzymes, blocking them before they can destroy the Cefpodoxime. This restores and extends the antibacterial activity of Cefpodoxime against resistant organisms. The combination is therefore effective in cases where plain Cefpodoxime has failed or where beta-lactamase-producing bacteria are suspected or confirmed.
Dosage and Administration
| Species |
Dose (Cefpodoxime component) |
Frequency |
Route |
| Dogs |
5–10 mg/kg body weight |
Once daily |
Oral |
| Cats |
5–10 mg/kg body weight (consult vet for adjustment) |
Once daily |
Oral |
Always administer with food — Cefpodoxime absorption is significantly enhanced with a fatty meal, and Clavulanate can cause gastrointestinal upset when given on an empty stomach. Weigh your pet before starting the course. Complete every dose of the prescribed course — stopping early with a beta-lactamase inhibitor combination is particularly risky as it selects for resistant bacterial populations.
When Is Cefpet CLV 325 Prescribed Instead of Plain Cefpet?
Your vet will prescribe Cefpet CLV 325 when:
- A bacterial infection has not responded adequately to plain Cefpodoxime (Cefpet 100mg or XL)
- Culture and sensitivity testing identifies a beta-lactamase-producing organism
- The infection type — deep skin infection, surgical wound, or recurrent UTI — is known to commonly involve resistant bacteria
It is a targeted second-step antibiotic. It is not a first-line treatment for all infections — your vet's diagnosis and prescription determines whether the combination is appropriate for your pet's specific case.
Important Information
- Prescription required — valid veterinary prescription must be provided at the time of order
- For oral use in dogs and cats only
- Do not stop the antibiotic course early even if your pet appears to have recovered
- Not for use in animals with known hypersensitivity to cephalosporin, penicillin, or beta-lactam antibiotics
- Inform your vet of all current medications before starting this course
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Frequently Asked Questions — Cefpet CLV 325 for Dogs
What is Cefpet CLV 325 and what does it treat? ▼
Cefpet CLV 325 is a combination antibiotic tablet by Intas Pharmaceuticals containing Cefpodoxime and Clavulanate. Cefpodoxime is a third-generation cephalosporin that kills bacteria by disrupting cell wall synthesis. Clavulanate is a beta-lactamase inhibitor — it blocks the enzyme that certain resistant bacteria use to inactivate cephalosporin antibiotics. Together, the combination is effective against bacterial infections caused by organisms that have developed resistance to standard cefpodoxime alone, including complicated skin infections, wound infections, and urinary tract infections in dogs.
Why is Clavulanate added to Cefpodoxime in Cefpet CLV? ▼
Some bacteria produce beta-lactamase enzymes that break down cephalosporin antibiotics, making standard antibiotic treatment ineffective. Clavulanate binds to and irreversibly inhibits these beta-lactamase enzymes, protecting Cefpodoxime from being destroyed. This restores and extends antibacterial activity against resistant strains. Cefpet CLV 325 is therefore prescribed when a bacterial infection has not responded to plain cefpodoxime, or when the infecting organism is known to be beta-lactamase-producing.
When does a vet prescribe Cefpet CLV 325 instead of plain Cefpet? ▼
Your vet will prescribe Cefpet CLV 325 when a bacterial infection has not responded adequately to standard cefpodoxime treatment, when culture and sensitivity testing identifies a beta-lactamase-producing organism, or when the infection type — such as deep skin infections, complicated wound infections, or recurrent urinary tract infections — is known to commonly involve resistant bacteria. It is a targeted second-step antibiotic, not a first-line choice for all infections.
Should Cefpet CLV 325 be given with food? ▼
Yes — always administer with food. Cefpodoxime absorption is significantly enhanced when given with a fatty meal. Clavulanate can cause gastrointestinal upset on an empty stomach. Giving with food reduces the risk of nausea, vomiting, and loose stools — the most commonly reported side effects with this combination. Maintain consistent dosing times each day to keep blood levels stable throughout the treatment course.
How long is a typical Cefpet CLV 325 treatment course? ▼
Course length depends on the infection type and depth. Superficial skin infections typically require 5–7 days. Deep or recurrent skin infections may need 4–6 weeks or longer. Urinary tract infections are generally treated for 5–10 days. Your vet may request a follow-up culture after initial treatment to confirm bacterial clearance before stopping the course. Never stop early — completing the full course is critical to prevent resistance development.
Can Cefpet CLV 325 be used in cats? ▼
Cefpet CLV 325 is labelled for dogs. Use in cats requires explicit veterinary guidance — cats metabolise certain drug combinations differently from dogs and are more sensitive to gastrointestinal side effects from clavulanate-containing products. Do not administer a dog-labelled combination antibiotic to a cat without your vet confirming the correct species-appropriate dose and frequency.
